Mouse Anti Human Leptin - mAHuLeptin



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Mouse Anti Human Leptin - mAHuLeptin

Background : Leptin inhibits food intake and stimulates energy expenditure. Leptin also has thermogenic actions and regulates enzymes of fatty acid oxidation. Severe hereditary obesity in rodents and humans is caused by defects in leptin production .In addition to its critical role in the physiologic regulation of body weight leptin has a variety of other physiologic and pathologic functions resembling those of cytokines . These functions include the regulation of hematopoiesis , angiogenesis , wound healing , inflammation , and immune responses.
Physical Apperance: Sterile Filtered White lyophilized (freeze-dried) powder.
Clone: YD-HLEP4B6
Isotype: Mouse IgG1
Reconstitution: Reconstitute with sterile H20. Mix gently, wash the sides of the vial and wait 30-60 seconds before use.
Formulation: 1 mg/ml in PBS .
Storage: Store at 4C, stable for 6 months. For long-term storage, store at -20C
Stability: Two years lyophilized, one month in solution at 4oC.
Titer: By direct ELISA, 1:10,000 dilution will yield 0.8 O.D using alkaline phosphatase conjugated rabbit anti-mouse Ig (Jackson Laboratories).
Usage: This material for research, laboratory or further evaluation purposes.
Latest Publications: Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth. cMillen IC, Muhlhausler BS, Yuen BS, roc Nutr Soc 2004 Aug;63(3):405-12 Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. i Z, Oben JA, Lin H, Diehl AM, epatology 2004 Aug;40(2):434-41 Both leptin and leptin-receptor are essential for apolipoprotein M expression in vivo. u N, Nilsson-Ehle P, Ahren B, iochem Biophys Res Commun 2004 Sep 3;321(4):916-21 Effects of exogenous leptin on satiety and satiation in patients with lipodystrophy and leptin insufficiency. cDuffie JR, Riggs PA, Freedman RJ, Clin Endocrinol Metab 2004 Sep;89(9):4258-63 Leptin and appetite control in lipodystrophy. hima R, Osei SY, Clin Endocrinol Metab 2004 Sep;89(9):4254-7 Augmentation of leptin and hypoxia-inducible factor 1alpha mRNAs in the pre-eclamptic placenta. wagaki S, Yokoyama Y, Takahashi Y, ynecol Endocrinol 2004 May;18(5):263-8